BIEN135 – Biophysics and Biothermodynamics
An introduction to the application of thermodynamic principles to understanding the behavior of biological systems. Discusses biophysical properties of biomacromolecules, such as proteins, polynucleotides, carbohydrates, and lipids, and methods of characterizing their properties and interactions.
The course has been originally designed By Prof. D. Morikis at UCR and discusses about the following topics:
- From genes to RNA and proteins
- Nucleic acid structure
- Glycans and lipids
- Protein structure
- Evolutionary variation of proteins
- Energy and intermolecular forces
- Linking energy and entropy: the Boltzmann distribution
- Free energy
- Chemical potential and the drive to equilibrium
Textbook: The Molecules of Life, Physical and Chemical Principles (2012) by John Kuriyan, Boyana Konforti, and David Wemmer, Garland Science, Taylor & Francis group. ISBN: 9780815341888. Paperback.
Computer Program:UCSF Chimera: https://www.cgl.ucsf.edu/chimera/
Computational Biophysics … coming soon @UCR
The focus of this class is to learn the foundations of biomoloecular modeling, starting from the basics of molecular dynamics (MD) simulations approaches to advanced simulation methods. The course will provide the basis for the development and application of biomolecular simulation techniques and for their applications in the fields of biophysics and bioengineering.
The course has been designed By Prof. G. Palermo at UCR and will discusses about the following topics:
- Introduction to bimolecular structure and dynamics
- Molecular Dynamics (MD) simulations: fundamental theory
- Free energy methods
- Enhanced sampling techniques
- Biased sampling techniques
- Analysis methods: Clustering and Principal Component Analysis
- Coarse Grained methods: model building and the Martini force field
- The hybrid Quantum Mechanics/Molecular Mechanics (QM/MM) approach
- Emerging methods for processing and refining cryo electron microscopy maps
- Overview of applications in biophysics and bioengineering
Textbook: (1) Andrew Leach: Molecular Modeling. Principles and Applications; (2) Tamar Schlick: Molecular Modeling and Simulations. An Interdisciplinary Guide
Computer Program:VMD, AMBER, GROMACS, CPMD
The course will be available soon at UCR!